Article
Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection.
Proceedings of the National Academy of Sciences of the United States of America - 22 Mar 2005
Betts Michael R, Exley Barbara, Price David A, Bansal Anju, Camacho Zenaido Tres, Teaberry Vanessa, West Sadie M, Ambrozak David R, Tomaras Georgia, Roederer Mario, Kilby J Michael, Tartaglia Jim, Belshe Robert, Gao Feng, Douek Daniel C, Weinhold Kent J, Koup Richard A, Goepfert Paul, Ferrari Guido
Abstract excerpt
Worldwide HIV-1 vaccine efforts are guided by the principle that HIV-specific T cell responses may provide protection from infection or delay overt disease. However, no clear correlates of T cell-mediated immune protection have been identified. Here, we examine in a HLA-B27(+) HIV seronegative vaccinee persistent HIV-specific vaccine-induced anti-Gag CD4(+) and CD8(+) T cell responses. Although these responses...
Topics
- AIDS Vaccines
- Adult
- Amino Acid Sequence
- Base Sequence
- CD4-Positive T-Lymphocytes
- CD8-Positive T-Lymphocytes
- DNA, Viral
- Gene Products, gag