Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Vaccine-induced HIV-specific CD8+ T cells utilize preferential HLA alleles and target-specific regions of HIV-1.

Journal of acquired immune deficiency syndromes (1999) - 1 Nov 2011

Friedrich David, Jalbert Emilie, Dinges Warren L, Sidney John, Sette Alessandro, Huang Yunda, McElrath M Juliana, Horton Helen

Abstract excerpt

Most T cell-based HIV-1 vaccine candidates induce responses of limited breadth for reasons that are unclear. We evaluated vaccine-induced T-cell responses in individuals receiving an HIV-1 recombinant adenoviral vaccine. Certain HLA alleles (B27, B57, B35, and B14) are preferentially utilized to mount HIV-specific responses, whereas other alleles (A02 and B07) are rarely utilized (P < 0.001). This preference...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to AIDS Vaccines
Share to Alleles

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to HLA Antigens

Share to Immunodominant Epitopes

Share to Vaccines, Synthetic

Source

Open in PubMed Open full text

Identifiers

PMID: 21709567
DOI: 10.1097/QAI.0b013e318228f992
PMCID: PMC3196811

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Vaccine-induced HIV-specific CD8+ T cells utilize preferential HLA alleles and target-specific regions of HIV-1.PMID 21709567Read ↗

Vaccine-induced gag-specific T cells are associated with reduced viremia after HIV-1 infection.Semantic proximity Read ↗

Lower Viral Loads and Slower CD4+ T-Cell Count Decline in MRKAd5 HIV-1 Vaccinees Expressing Disease-Susceptible HLA-B*58:02.Semantic proximity Read ↗

Virus-specific CD8+ T-cell responses better define HIV disease progression than HLA genotype.Semantic proximity Read ↗

Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection.Semantic proximity Read ↗

Comparing CD8+ T cell ENV epitopes of two HLA class I alleles associated with different outcomes of HIV-1 infection with broadly neutralizing antibodies epitope targets discovered to date.Semantic proximity Read ↗

Elevated HIV Infection of CD4 T Cells in MRKAd5 Vaccine Recipients Due to CD8 T Cells Targeting Adapted Epitopes.Semantic proximity Read ↗

Prediction of differential Gag versus Env responses to a mosaic HIV-1 vaccine regimen by HLA class I alleles.Semantic proximity Read ↗

Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines.Semantic proximity Read ↗

For protection from HIV-1 infection, more might not be better: a systematic analysis of HIV Gag epitopes of two alleles associated with different outcomes of HIV-1 infection.Semantic proximity Read ↗

The challenges of host and viral diversity in HIV vaccine design.Semantic proximity Read ↗

Generating and measuring effective vaccine-elicited HIV-specific CD8+ T cell responsesSemantic proximity Read ↗

Clinical Control of HIV-1 by Cytotoxic T Cells Specific for Multiple Conserved EpitopesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.