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Article

Lower Viral Loads and Slower CD4+ T-Cell Count Decline in MRKAd5 HIV-1 Vaccinees Expressing Disease-Susceptible HLA-B*58:02.

The Journal of infectious diseases - 1 Aug 2016

Leitman Ellen M, Hurst Jacob, Mori Masahiko, Kublin James, Ndung'u Thumbi, Walker Bruce D, Carlson Jonathan, Gray Glenda E, Matthews Philippa C, Frahm Nicole, Goulder Philip J R

Abstract excerpt

BACKGROUND: HLA strongly influences human immunodeficiency virus type 1 (HIV-1) disease progression. A major contributory mechanism is via the particular HLA-presented HIV-1 epitopes that are recognized by CD8(+) T-cells. Different populations vary considerably in the HLA alleles expressed. We investigated the HLA-specific impact of the MRKAd5 HIV-1 Gag/Pol/Nef vaccine in a subset of the infected Phambili cohort...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26951820
DOI: 10.1093/infdis/jiw093
PMCID: PMC4936641

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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