Article
Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individuals.
Proceedings of the National Academy of Sciences of the United States of America - 16 Sept 2014
Hu Haitao, Eller Michael A, Zafar Shah, Zhou Yu, Gu Mengnan, Wei Zhi, Currier Jeffrey R, Marovich Mary A, Kibuuka Hannah N, Bailer Robert T, Koup Richard A, Robb Merlin L, Michael Nelson L, Kim Jerome H, Ratto-Kim Silvia
Abstract excerpt
Efficacy trials of adenovirus 5-vectored candidate HIV vaccines [recombinant Ad5 (rAd5)-HIV] were halted for futility due to lack of vaccine efficacy and unexpected excess HIV infections in the vaccine recipients. The potential immunologic basis for these observations is unclear. We comparatively evaluated the HIV susceptibility and phenotypes of human CD4 T cells specific to Ad5 and CMV, two viruses that have...
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