Article
Genotypic Diversity among Angolan Children with Sickle Cell Anemia.
International journal of environmental research and public health - 19 May 2021
Delgadinho Mariana, Ginete Catarina, Santos Brígida, Miranda Armandina, Brito Miguel
Abstract excerpt
BACKGROUND: Sickle cell anemia (SCA) is an inherited blood disorder that affects over 300,000 newborns worldwide every year, being particularly prevalent in Sub-Saharan Africa. Despite being a monogenic disease, SCA shows a remarkably high clinical heterogeneity. Several studies have already demonstrated the existence of some polymorphisms that can provide major clinical benefits, producing a mild phenotype....
Topics
- Anemia, Sickle Cell
- Child
- Fetal Hemoglobin
- Genotype
- Haplotypes
- Humans
- Infant, Newborn
- Polymorphism, Single Nucleotide
- Repressor Proteins