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Genetic patterns & public health implications of sickle cell anaemia across populations: A systematic review.

The Indian journal of medical research - 1 Nov 2025

Shrivastava Manisha, Bathri Rashmi, Shafqat Naseema, Das Saikat, Agrawal Amit

Abstract excerpt

Background & objectives Sickle cell anaemia (SCA) is a serious inherited blood disorder caused by mutations in the β-globin gene, leading to abnormal haemoglobin (HbS). Understanding the genetic diversity of SCA is important for improving diagnosis, treatment, and public health planning. Our aim was to systematically review and summarise the genetic variations associated with SCA in various populations, and to...

Topics

Humans
Anemia, Sickle Cell
Public Health
beta-Globins
beta-Thalassemia
Hemoglobinopathies
Haplotypes
Mutation
Saudi Arabia
alpha-Thalassemia
Iran

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Open in PubMed Open full text

Identifiers

PMID: 41520274
DOI: 10.25259/IJMR_1288_2025
PMCID: PMC12826371

Genes

BCL11A
MYH9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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