Article
Genetic modulation of anemia severity, hemolysis level, and hospitalization rate in Angolan children with Sickle Cell Anemia.
Molecular biology reports - 1 Nov 2022
Germano Isabel, Santos Brígida, Delgadinho Mariana, Ginete Catarina, Lopes Pedro, Arez Ana Paula, Brito Miguel, Faustino Paula
Abstract excerpt
BACKGROUND: Sickle Cell Anemia (SCA) is a genetic disease caused by the c.20 A > T mutation in HBB gene, generally characterized by sickle erythrocytes, chronic hemolytic anemia, and vaso-occlusive events. This study aimed to investigate genetic modulators of anemia severity, chronic hemolytic rate, and clinical manifestations in pediatric SCA patients from Angola, where the disease is a severe public health...
Topics
- Humans
- Hemolysis
- Anemia, Sickle Cell
- Erythrocytes
- Alleles
- Hospitalization