Co-Inheritance of alpha-thalassemia and sickle cell disease in a cohort of Angolan pediatric patients.

doi:10.1007/s11033-020-05628-8

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Article

Co-Inheritance of alpha-thalassemia and sickle cell disease in a cohort of Angolan pediatric patients.

Molecular biology reports - 1 Jul 2020

Santos Brígida, Delgadinho Mariana, Ferreira Joana, Germano Isabel, Miranda Armandina, Arez Ana Paula, Faustino Paula, Brito Miguel

Abstract excerpt

The aim of this study was to explore the association between alpha-thalassemia, fetal hemoglobin, hematological indices, and clinical adverse events in Angolan sickle cell disease pediatric patients. A total of 200 sickle cell disease (SCD) children were sampled in Luanda and Caxito. A venous blood sample was collected and used for hematological analyses, fetal hemoglobin quantification, and genotyping of 3.7 kb...

Topics

Adolescent
Anemia, Sickle Cell
Angola
Child
Child, Preschool
Cohort Studies
Comorbidity
Erythrocyte Indices
Female
Fetal Hemoglobin
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hemolysis

Heterozygote

Homozygote

Humans

Male

alpha-Thalassemia

Source

Open in PubMed

Identifiers

PMID: 32632780
DOI: 10.1007/s11033-020-05628-8

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