Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A genetic risk score based on BCL11A and HBS1L-MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients.

British journal of haematology - 1 Jun 2026

Arcanjo Gabriela S, Silva Alexsandro P, Diniz Madi V, Domingos Igor F, Pereira-Martins Diego A, Araújo Amanda B, França Talita S S, Anjos Ana C, Araujo Aderson S, Belini-Junior Edis, Saad Sara T O, Costa Fernando F, Lucena-Araujo Antonio R, Bezerra Marcos André C

Abstract excerpt

Individuals with sickle cell anaemia (SCA) exhibit significant clinical heterogeneity influenced by several factors, especially fetal haemoglobin (HbF) levels. Variations in adult HbF levels are partly explained by the co-inheritance of genetic variants that regulate globin expression. In this study, we investigated the association of BCL11A rs4671393, rs1427407, rs11886868 and HBS1L-MYB rs9399137 polymorphisms...

Read the complete abstract on PubMed

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anemia, Sickle Cell
Share to Brazil
Share to Fetal Hemoglobin
Share to Genetic Risk Score
Share to GTP-Binding Proteins
Share to Peptide Elongation Factors
Share to Proto-Oncogene Proteins c-myb
Share to Severity of Illness Index

Source

Open in PubMed Open full text

Identifiers

PMID: 41989145
DOI: 10.1111/bjh.70489
PMCID: PMC13267477

Genes

BCL11A
HBS1L
MYB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A genetic risk score based on BCL11A and HBS1L-MYB variants predicts clinical severity in Brazilian sickle cell anaemia patients.PMID 41989145Read ↗

Functional polymorphisms of BCL11A and HBS1L-MYB genes affect both fetal hemoglobin level and clinical outcomes in a cohort of children with sickle cell anemia.Semantic proximity Read ↗

Influence of single nucleotide polymorphisms in the BCL11A and HBS1L-MYB gene on the HbF levels and clinical severity of sickle cell anaemia patientsSemantic proximity Read ↗

Fetal hemoglobin-boosting haplotypes of BCL11A gene and HBS1L-MYB intergenic region in the prediction of clinical and hematological outcomes in a cohort of children with sickle cell anemia.Semantic proximity Read ↗

rs11886868 and rs4671393 of BCL11A associated with HbF level variation and modulate clinical events among sickle cell anemia patients.Semantic proximity Read ↗

Genetic Modifiers of Sickle Cell Anemia Phenotype in a Cohort of Angolan Children.Semantic proximity Read ↗

Pleiotropic Effects of Polymorphisms in the <em>BCL11A</em> Gene on Laboratory Parameters in Sickle Cell AnemiaSemantic proximity Read ↗

DNA polymorphisms at BCL11A, HBS1L-MYB and Xmn1-HBG2 site loci associated with fetal hemoglobin levels in sickle cell anemia patients from Northern Brazil.Semantic proximity Read ↗

Genetic variant in the BCL11A (rs1427407), but not HBS1-MYB (rs6934903) loci associate with fetal hemoglobin levels in Indian sickle cell disease patients.Semantic proximity Read ↗

DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease.Semantic proximity Read ↗

Genetic Variation and Sickle Cell Disease Severity: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

Genetics of fetal hemoglobin in tribal Indian patients with sickle cell anemia.Semantic proximity Read ↗

Genetic etiologies for phenotypic diversity in sickle cell anemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.