Article
Genotyping the BCL11A Single Nucleotide Polymorphism and Associated Levels of Fetal Hemoglobin in Mauritanian Sickle Cell Patients.
Frontiers in bioscience (Scholar edition) - 12 Jun 2024
Taleb Brahim Aminetou, Taleb Mariem, Soumaré Harouna, Ghaber Sidi Mohamed, Mohamed Aminetou, Ould Mohamed Salem Boukhary Ali
Abstract excerpt
BACKGROUND: Sickle cell disease (SCD) is a major heritable genetic disease in sub-Saharan Africa, including Mauritania. Fetal hemoglobin (HbF) can affect the pathophysiology, moderate the clinical course, and offer prospects for curative treatment of SCD. This study aimed to investigate the influence of single nucleotide polymorphisms (SNPs) in the BCL11A gene on the levels of HbF and hematological parameters in...
Topics
- Humans
- Fetal Hemoglobin
- Anemia, Sickle Cell
- Polymorphism, Single Nucleotide
- Female
- Male
- Adult
- Repressor Proteins
- Mauritania
- Genotype
- Nuclear Proteins
- Adolescent
- Carrier Proteins
- Young Adult
- Child