Sickle cell anemia: clinical diversity and beta S-globin haplotypes

Abstract excerpt

probably as a consequence of the domestic slave trade and subsequent internal migrations from other regions of Brazil.Fetal hemoglobin (Hb F) is related to the haplotype and correlates with the clinical course of SCA. SEN and ARAB haplotypes produce the highest levels of Hb F and are associated with fewer clinical manifestations of SCA and with a lower occurrence of organ damage. BEN and CAM haplotypes exhibit...

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