Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetics and Genomics in Sickle Cell Disease in Africa.

American journal of hematology - 1 Apr 2026

Nkya Siana, Makani Julie, Flanagan Jonathan M

Abstract excerpt

Advanced genomic technologies are revolutionizing our ability to understand complex diseases. Large-scale population studies are needed to realize the potential of using individual genetic information to personalize treatments for better patient outcomes for chronic non-communicable diseases, such as sickle cell disease (SCD). SCD is recognized as a benchmark genetic disorder for study both in Africa and globally...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Africa
Share to Anemia, Sickle Cell
Share to Apolipoprotein L1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fetal Hemoglobin

Share to Genetic Variation

Share to Genomics

Share to Hydroxyurea

Share to Pharmacogenetics

Source

Open in PubMed Open full text

Identifiers

PMID: 41830511
DOI: 10.1002/ajh.70220
PMCID: PMC12988568

Genes

SCD
APOL1
BCL11A
FLT1
KLF1
MYB

Provenance

PubMed metadata and Literature Corpus relationships.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetics and Genomics in Sickle Cell Disease in Africa.PMID 41830511Read ↗

The future of sickle cell disease therapeutics rests in genomicsSemantic proximity Read ↗

Identifying genetic variants and pathways associated with extreme levels of fetal hemoglobin in sickle cell disease in Tanzania.Semantic proximity Read ↗

Sickle cell disease and H3Africa: enhancing genomic research on cardiovascular diseases in African patients.Semantic proximity Read ↗

Identifying genetic variants and pathways associated with extreme levels of fetal hemoglobin in Sickle Cell Disease in Tanzania.Semantic proximity Read ↗

Exploring pharmacogenetic factors influencing hydroxyurea response in tanzanian sickle cell disease patients: a genomic medicine approach.Semantic proximity Read ↗

Genetic Variation and Sickle Cell Disease Severity: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

A replication study of novel fetal hemoglobin-associated genetic variants in sickle cell disease-only cohorts.Semantic proximity Read ↗

Exploring Pharmacogenetic Factors Influencing Hydroxyurea Response in Tanzanian Sickle Cell Disease Patients: A Genomic Medicine ApproachSemantic proximity Read ↗

Genetic Modifiers of Sickle Cell Anemia Phenotype in a Cohort of Angolan Children.Semantic proximity Read ↗

An Analysis of Racial and Ethnic Backgrounds Within the CASiRe International Cohort of Sickle Cell Disease Patients: Implications for Disease Phenotype and Clinical Research.Semantic proximity Read ↗

Genome wide association study of fetal hemoglobin in sickle cell anemia in Tanzania.Semantic proximity Read ↗

Perspectives in Genetics and Sickle Cell Disease Prevention in Africa: Beyond the Preliminary Data from Cameroon.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.