Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell image analysis reveals a protective role for microglia in glioblastoma

1 Jan 2021

Abstract excerpt

BACKGROUND: Microglia and tumor-associated macrophages (TAMs) constitute up to half of the total tumor mass of glioblastomas. Despite these myeloid populations being ontogenetically distinct, they have been largely conflated. Recent single-cell transcriptomic studies have identified genes that distinguish microglia from TAMs. Here we investigated whether the translated proteins of genes enriched in microglial or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glioma Diagnosis and Treatment
Share to Immune cells in cancer
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34286275
DOI: 10.1093/noajnl/vdab031

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell image analysis reveals a protective role for microglia in glioblastomaPMID 34286275Read ↗

Dynamics of glioma-associated microglia and macrophages reveals their divergent roles in the immune response of brainSemantic proximity Read ↗

Single-cell profiling of human gliomas reveals macrophage ontogeny as a basis for regional differences in macrophage activation in the tumor microenvironmentSemantic proximity Read ↗

Single-cell characterization of macrophages in glioblastoma reveals MARCO as a mesenchymal pro-tumor marker.Semantic proximity Read ↗

Single-cell RNA sequencing reveals functional heterogeneity of glioma-associated brain macrophages.Semantic proximity Read ↗

Single-Cell Transcriptomics of Glioblastoma Reveals a Unique Tumor Microenvironment and Potential Immunotherapeutic Target Against Tumor-Associated MacrophageSemantic proximity Read ↗

Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenograftsSemantic proximity Read ↗

Macrophages/Microglia in the Glioblastoma Tumor MicroenvironmentSemantic proximity Read ↗

Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts.Semantic proximity Read ↗

Single-cell RNA sequencing reveals functional heterogeneity and sex differences of glioma-associated brain macrophagesSemantic proximity Read ↗

Glioma-Associated Microglia/Macrophages Display an Expression Profile Different from M1 and M2 Polarization and Highly Express Gpnmb and Spp1Semantic proximity Read ↗

A transcriptome-defined TAM-rich phenotype identifies a macrophage-enriched, hypoxia-linked immune contexture in glioblastoma: multi-cohort transcriptomic validation and local histopathological correlation.Semantic proximity Read ↗

Distinct regional ontogeny and activation of tumor associated macrophages in human glioblastomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.