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Article

Single-Cell Transcriptomics of Glioblastoma Reveals a Unique Tumor Microenvironment and Potential Immunotherapeutic Target Against Tumor-Associated Macrophage

9 Aug 2021

Abstract excerpt

BACKGROUND: The main immune cells in GBM are tumor-associated macrophages (TAMs). Thus far, the studies investigating the activation status of TAM in GBM are mainly limited to bulk RNA analyses of individual tumor biopsies. The activation states and transcriptional signatures of TAMs in GBM remain poorly characterized. METHODS: We comprehensively analyzed single-cell RNA-sequencing data, covering a total of...

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PMID: 34434898
DOI: 10.3389/fonc.2021.710695

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