Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma.

doi:10.1186/s13059-020-02140-x

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Article

Transcriptional regulatory networks of tumor-associated macrophages that drive malignancy in mesenchymal glioblastoma.

Genome biology - 26 Aug 2020

Sa Jason K, Chang Nakho, Lee Hye Won, Cho Hee Jin, Ceccarelli Michele, Cerulo Luigi, Yin Jinlong, Kim Sung Soo, Caruso Francesca P, Lee Mijeong, Kim Donggeon, Oh Young Taek, Lee Yeri, Her Nam-Gu, Min Byeongkwi, Kim Hye-Jin, Jeong Da Eun, Kim Hye-Mi, Kim Hyunho, Chung Seok, Woo Hyun Goo, Lee Jeongwu, Kong Doo-Sik, Seol Ho Jun, Lee Jung-Il, Kim Jinho, Park Woong-Yang, Wang Qianghu, Sulman Erik P, Heimberger Amy B, Lim Michael, Park Jong Bae, Iavarone Antonio, Verhaak Roel G W, Nam Do-Hyun

Abstract excerpt

BACKGROUND: Glioblastoma (GBM) is a complex disease with extensive molecular and transcriptional heterogeneity. GBM can be subcategorized into four distinct subtypes; tumors that shift towards the mesenchymal phenotype upon recurrence are generally associated with treatment resistance, unfavorable prognosis, and the infiltration of pro-tumorigenic macrophages. RESULTS: We explore the transcriptional regulatory...

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Identifiers

PMID: 32847614
DOI: 10.1186/s13059-020-02140-x
PMCID: PMC7448990

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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