Article
Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow-Derived Macrophages.
Cancer research - 2 Mar 2023
Wu Min, Wu Lingxiang, Wu Wei, Zhu Mengyan, Li Jianyu, Wang Ziyu, Li Jie, Ding Rong, Liang Yuan, Li Liangyu, Zhang Tingting, Huang Bin, Cai Yun, Li Kening, Li Lu, Zhang Rui, Hu Baoli, Lin Fan, Wang Xiuxing, Zheng Siyuan, Chen Jian, You Yongping, Jiang Tao, Zhang Junxia, Chen Hongshan, Wang Qianghu
Abstract excerpt
Tumor-associated macrophages (TAM) play a crucial role in immunosuppression. However, how TAMs are transformed into immunosuppressive phenotypes and influence the tumor microenvironment (TME) is not fully understood. Here, we utilized single-cell RNA sequencing and whole-exome sequencing data of glioblastoma (GBM) tissues and identified a subset of TAMs dually expressing macrophage and tumor signatures, which...
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