Article
SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site.
Communications biology - 5 May 2021
Allen Mark D, Freund Stefan M V, Bycroft Mark, Zinzalla Giovanna
Abstract excerpt
SWI/SNF (BAF) chromatin remodelling complexes are key regulators of gene expression programs, and attractive drug targets for cancer therapies. Here we show that the N-terminus of the BAF155/SMARCC1 subunit contains a putative DNA-binding MarR-like domain, a chromodomain and a BRCT domain that are interconnected to each other to form a distinct module. In this structure the chromodomain makes interdomain...
Topics
- Binding Sites
- Humans
- Models, Molecular
- Mutation
- Neoplasms
- Pharmaceutical Preparations
- Protein Conformation
- Transcription Factors