Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing.

Cell - 10 Jun 2021

Mendel Mateusz, Delaney Kamila, Pandey Radha Raman, Chen Kuan-Ming, Wenda Joanna M, Vågbø Cathrine Broberg, Steiner Florian A, Homolka David, Pillai Ramesh S

Abstract excerpt

The N6-methyladenosine (m6A) RNA modification is used widely to alter the fate of mRNAs. Here we demonstrate that the C. elegans writer METT-10 (the ortholog of mouse METTL16) deposits an m6A mark on the 3' splice site (AG) of the S-adenosylmethionine (SAM) synthetase pre-mRNA, which inhibits its proper splicing and protein production. The mechanism is triggered by a rich diet and acts as an m6A-mediated switch...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine
Share to Methionine Adenosyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methyltransferases

Share to RNA Precursors

Share to RNA, Small Nuclear

Share to RNA Splice Sites

Share to S-Adenosylmethionine

Share to Splicing Factor U2AF

Source

Open in PubMed Open full text

Identifiers

PMID: 33930289
DOI: 10.1016/j.cell.2021.03.062
PMCID: PMC8208822

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Splice site m6A methylation prevents binding of U2AF35 to inhibit RNA splicing.PMID 33930289Read ↗

The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs.Semantic proximity Read ↗

The regulatory role of m6A modification in the maintenance and differentiation of embryonic stem cellsSemantic proximity Read ↗

m6A in the coding sequence: linking deposition, translation, and decaySemantic proximity Read ↗

Reading and writing of mRNA m6A modification orchestrate maternal-to-zygotic transition in miceSemantic proximity Read ↗

m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiationSemantic proximity Read ↗

N6-Adenosine methylation regulates the translation of insulin mRNASemantic proximity Read ↗

METTL4 catalyzes m6Am methylation in <i>U2 snRNA</i> to regulate pre-mRNA splicingSemantic proximity Read ↗

m <sup>6</sup> A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5’ splice siteSemantic proximity Read ↗

Vitamin B <sub>12</sub> alleviates Verheij syndrome-like defects via phospholipid remodeling in a <i>C. elegans</i> PUF60 spliceosomopathy modelSemantic proximity Read ↗

N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3'-end processing.Semantic proximity Read ↗

m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells.Semantic proximity Read ↗

Sequence- and structure-specific cytosine-5 mRNA methylation by NSUN6Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.