Article

N6-Adenosine methylation regulates the translation of insulin mRNA

2022-09-20

Abstract excerpt

Relatively little is known about the first step of insulin synthesis: the translation of the mRNA. Here we show that the translation of D. melanogaster insulin 2 mRNA ( dilp2 ) is controlled by methylation of N6-adenosine (m 6 A) in the 3’ UTR. Mutations in the m 6 A writer Mettl3 and methylated-residues in the dilp2 3’UTR decreased the levels of dilp2 mRNA associated with the polysomes, and the total amoun...

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Literature Corpus work: 7bed5466-b6f2-5412-8abe-1b66e024792b
DOI: 10.1101/2022.09.20.508712

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