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m6A mRNA methylation by METTL14 regulates early pancreatic cell differentiation

25 Sept 2024

Abstract excerpt

Abstract N 6 -methyladenosine (m 6 A) is the most abundant chemical modification in mRNA and plays important roles in human and mouse embryonic stem cell pluripotency, maintenance, and differentiation. We have recently reported that m 6 A is involved in the postnatal control of β-cell function in physiological states and in type 1 and 2 diabetes. However, the precise mechanisms by which m 6 A acts to regulate the...

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PMID: 39322760
DOI: 10.1038/s44318-024-00213-2

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