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m6A in the coding sequence: linking deposition, translation, and decay

7 Jul 2025

Abstract excerpt

N 6-methyladenosine (m 6 A) is the most abundant internal modification in mRNA and plays a crucial role in regulating mRNA turnover. This review explores the characteristics of m 6 A sites in the coding sequence (CDS) and their influence on mRNA decay, with a focus on the newly discovered CDS–m 6 A decay (CMD) pathway – a translation-dependent mechanism that promotes rapid and efficient degradation. Further, we...

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PMID: 40628588
DOI: 10.1016/j.tig.2025.06.002

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