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Article

N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3'-end processing.

Nucleic acids research - 2 Nov 2017

Bartosovic Marek, Molares Helena Covelo, Gregorova Pavlina, Hrossova Dominika, Kudla Grzegorz, Vanacova Stepanka

Abstract excerpt

N6-methyladenosine (m6A) is the most abundant base modification found in messenger RNAs (mRNAs). The discovery of FTO as the first m6A mRNA demethylase established the concept of reversible RNA modification. Here, we present a comprehensive transcriptome-wide analysis of RNA demethylation and uncover FTO as a potent regulator of nuclear mRNA processing events such as alternative splicing and 3΄ end mRNA...

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Source

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Identifiers

PMID: 28977517
DOI: 10.1093/nar/gkx778
PMCID: PMC5737695

Genes

FTO
METTL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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