Article

m <sup>6</sup> A modification of U6 snRNA modulates usage of two major classes of pre-mRNA 5’ splice site

2022-04-05

Abstract excerpt

Alternative splicing of messenger RNAs is associated with the evolution of developmentally complex eukaryotes. Splicing is mediated by the spliceosome, and docking of the pre-mRNA 5’ splice site into the spliceosome active site depends upon pairing with the conserved ACAGA sequence of U6 snRNA. In some species, including humans, the central adenosine of the AC A GA box is modified by N 6 methylation, but the ro...

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Literature Corpus work: 1133cf19-8646-5447-bdf1-31bb8f14a24b
DOI: 10.1101/2022.04.05.487178

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