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Article

m(6)A RNA modification controls cell fate transition in mammalian embryonic stem cells.

Cell stem cell - 4 Dec 2014

Batista Pedro J, Molinie Benoit, Wang Jinkai, Qu Kun, Zhang Jiajing, Li Lingjie, Bouley Donna M, Lujan Ernesto, Haddad Bahareh, Daneshvar Kaveh, Carter Ava C, Flynn Ryan A, Zhou Chan, Lim Kok-Seong, Dedon Peter, Wernig Marius, Mullen Alan C, Xing Yi, Giallourakis Cosmas C, Chang Howard Y

Abstract excerpt

N6-methyl-adenosine (m(6)A) is the most abundant modification on messenger RNAs and is linked to human diseases, but its functions in mammalian development are poorly understood. Here we reveal the evolutionary conservation and function of m(6)A by mapping the m(6)A methylome in mouse and human embryonic stem cells. Thousands of messenger and long noncoding RNAs show conserved m(6)A modification, including...

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Identifiers

PMID: 25456834
DOI: 10.1016/j.stem.2014.09.019
PMCID: PMC4278749

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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