Article
[Mutation signatures in head and neck squamous cell carcinoma : Pathogenesis and therapeutic potential].
HNO - 1 Dec 2020
Plath M, Hess J, Zaoui K
Abstract excerpt
BACKGROUND: The pathogenesis of head and neck squamous cell carcinoma (HNSCC) is a complex and multistage process which results from the interaction of exogenous and endogenous cellular processes. Each of these processes leaves a characteristic pattern of mutations on the tumor genome, a so-called mutational signature. STATE OF THE ART: The subject of current studies is to decipher specific signatures of...
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