Article
Mutational landscape of aggressive cutaneous squamous cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Dec 2014
Pickering Curtis R, Zhou Jane H, Lee J Jack, Drummond Jennifer A, Peng S Andrew, Saade Rami E, Tsai Kenneth Y, Curry Jonathan L, Tetzlaff Michael T, Lai Stephen Y, Yu Jun, Muzny Donna M, Doddapaneni Harshavardhan, Shinbrot Eve, Covington Kyle R, Zhang Jianhua, Seth Sahil, Caulin Carlos, Clayman Gary L, El-Naggar Adel K, Gibbs Richard A, Weber Randal S, Myers Jeffrey N, Wheeler David A, Frederick Mitchell J
Abstract excerpt
PURPOSE: Aggressive cutaneous squamous cell carcinoma (cSCC) is often a disfiguring and lethal disease. Very little is currently known about the mutations that drive aggressive cSCC. EXPERIMENTAL DESIGN: Whole-exome sequencing was performed on 39 cases of aggressive cSCC to identify driver genes and novel therapeutic targets. Significantly, mutated genes were identified with MutSig or complementary methods...
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