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Article

Multi-modality analysis supports APOBEC as a major source of mutations in head and neck squamous cell carcinoma.

Oral oncology - 1 Nov 2017

Faden Daniel L, Thomas Sean, Cantalupo Paul G, Agrawal Nishant, Myers Jeffrey, DeRisi Joseph

Abstract excerpt

OBJECTIVES: The mutagenic processes underlying head and neck squamous cell carcinoma (HNSCC) are poorly understood. Pan-cancer mutational signature analyses have identified a signature for APOBEC, a cytosine deaminase, in a subset of cancers, including HNSCC. The role of APOBEC activity in HNSCC remains poorly understood. Therefore, we sought to determine the role of APOBEC in HNSCC pathogenesis. MATERIAL AND...

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Share to Carcinoma, Squamous Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29103756
DOI: 10.1016/j.oraloncology.2017.09.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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