Article
The mutational landscape of head and neck squamous cell carcinoma.
Science (New York, N.Y.) - 26 Aug 2011
Stransky Nicolas, Egloff Ann Marie, Tward Aaron D, Kostic Aleksandar D, Cibulskis Kristian, Sivachenko Andrey, Kryukov Gregory V, Lawrence Michael S, Sougnez Carrie, McKenna Aaron, Shefler Erica, Ramos Alex H, Stojanov Petar, Carter Scott L, Voet Douglas, Cortés Maria L, Auclair Daniel, Berger Michael F, Saksena Gordon, Guiducci Candace, Onofrio Robert C, Parkin Melissa, Romkes Marjorie, Weissfeld Joel L, Seethala Raja R, Wang Lin, Rangel-Escareño Claudia, Fernandez-Lopez Juan Carlos, Hidalgo-Miranda Alfredo, Melendez-Zajgla Jorge, Winckler Wendy, Ardlie Kristin, Gabriel Stacey B, Meyerson Matthew, Lander Eric S, Getz Gad, Golub Todd R, Garraway Levi A, Grandis Jennifer R
Abstract excerpt
Head and neck squamous cell carcinoma (HNSCC) is a common, morbid, and frequently lethal malignancy. To uncover its mutational spectrum, we analyzed whole-exome sequencing data from 74 tumor-normal pairs. The majority exhibited a mutational profile consistent with tobacco exposure; human papillomavirus was detectable by sequencing DNA from infected tumors. In addition to identifying previously known HNSCC genes...
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