Article
Effects of Periconceptional Multivitamin Supplementation on Folate and Homocysteine Levels Depending on Genetic Variants of Methyltetrahydrofolate Reductase in Infertile Japanese Women.
Nutrients - 20 Apr 2021
Kuroda Keiji, Horikawa Takashi, Gekka Yoko, Moriyama Azusa, Nakao Kazuki, Juen Hiroyasu, Takamizawa Satoru, Ojiro Yuko, Nakagawa Koji, Sugiyama Rikikazu
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR) has various polymorphisms, and the effects of periconceptional folic acid supplementation for decreasing neural tube defects (NTDs) risk differ depending on the genotypes. This study analyzed the effectiveness of multivitamin supplementation on folate insufficiency and hyperhomocysteinemia, depending on MTHFR polymorphisms. Of 205 women, 72 (35.1%), 100 (48.8%) and 33...
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