Article
MTHFR 677C->T genotype is associated with folate and homocysteine concentrations in a large, population-based, double-blind trial of folic acid supplementation.
The American journal of clinical nutrition - 1 Jun 2011
Crider Krista S, Zhu Jiang-Hui, Hao Ling, Yang Quan-He, Yang Thomas P, Gindler Jacqueline, Maneval David R, Quinlivan Eoin P, Li Zhu, Bailey Lynn B, Berry Robert J
Abstract excerpt
BACKGROUND: The methylenetetrahydrofolate reductase (MTHFR) genotype is associated with modification of disease and risk of neural tube defects. Plasma and red blood cell (RBC) folate and plasma homocysteine concentrations change in response to daily intakes of folic acid supplements, but no large-scale or population-based randomized trials have examined whether the MTHFR genotype modifies the observed response....
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