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Perspectives on folate with special reference to epigenetics and neural tube defects

12 Mar 2024

Abstract excerpt

Folate is a micronutrient essential for DNA synthesis, cell division, fetal growth and development. Folate deficiency leads to genomic instability. Inadequate intake of folate during conception may lead to neural tube defects (NTDs) in the offspring. Folate influences the DNA methylation, histone methylation and homocysteine mediated gene methylation. DNA methylation influences the expression of microRNAs...

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PMID: 38479591
DOI: 10.1016/j.reprotox.2024.108576

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