Investigations of single nucleotide polymorphisms in folate pathway genes in Chinese families with neural tube defects.

doi:10.1016/j.jns.2013.11.017

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Investigations of single nucleotide polymorphisms in folate pathway genes in Chinese families with neural tube defects.

Journal of the neurological sciences - 15 Feb 2014

Liu Jian, Qi Jing, Yu Xiao, Zhu Jie, Zhang Lixia, Ning Qin, Luo Xiaoping

Abstract excerpt

AIMS: We investigated the hypothesis that there are interactions between SNPs in folate metabolism pathway genes and environmental risk factors to the etiology of neural tube defects (NTDs). METHOD: In 602 Chinese families, 609 aborted fetus tissues or blood samples were collected from NTD individuals, and 1106 parental blood samples were detected as controls. We analyzed 28 SNPs in 12 folate pathway genes....

Topics

Betaine-Homocysteine S-Methyltransferase
China
Family Health
Female
Ferredoxin-NADP Reductase
Folic Acid
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Methylenetetrahydrofolate Reductase (NADPH2)

Neural Tube Defects

Polymorphism, Single Nucleotide

Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 24326202
DOI: 10.1016/j.jns.2013.11.017

Genes

BHMT
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Investigations of single nucleotide polymorphisms in folate pathway genes in Chinese families with neural tube defects.PMID 24326202Read ↗

Polymorphisms in MTHFD1 Gene and Susceptibility to Neural Tube Defects: A Case-Control Study in a Chinese Han Population with Relatively Low Folate Levels.Semantic proximity Read ↗

Association of main folate metabolic pathway gene polymorphisms with neural tube defects in Han population of Northern China.Semantic proximity Read ↗

Variants in MTHFR gene and neural tube defects susceptibility in China.Semantic proximity Read ↗

"Polymorphisms in folate metabolism genes as maternal risk factor for neural tube defects: an updated meta-analysis".Semantic proximity Read ↗

Correlation analysis of MTHFD1 gene polymorphisms and neural tube defects in Han population of Northern ChinaSemantic proximity Read ↗

Study on the relationship between genetic polymorphism of reductive folic acid carrier and the risk of neural tube defects.Semantic proximity Read ↗

Association between MTHFD1 polymorphisms and neural tube defect susceptibility.Semantic proximity Read ↗

Genetic variants in the folate pathway and the risk of neural tube defects: a meta-analysis of the published literature.Semantic proximity Read ↗

Analysis of polymorphisms of genes associated with folate-mediated one-carbon metabolism and neural tube defects in Chinese Han Population.Semantic proximity Read ↗

Neural tube defects and folate pathway genes: family-based association tests of gene-gene and gene-environment interactions.Semantic proximity Read ↗

Analysis of MTR and MTRR Polymorphisms for Neural Tube Defects Risk Association.Semantic proximity Read ↗

Association of the maternal MTHFR C677T polymorphism with susceptibility to neural tube defects in offsprings: evidence from 25 case-control studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.