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Article

Polymorphisms in MTHFD1 Gene and Susceptibility to Neural Tube Defects: A Case-Control Study in a Chinese Han Population with Relatively Low Folate Levels.

Medical science monitor : international medical journal of experimental and clinical research - 4 Sept 2015

Wu Jian, Bao Yihua, Lu Xiaolin, Wu Lihua, Zhang Ting, Guo Jin, Yang Jian

Abstract excerpt

BACKGROUND: The polymorphism of methylenetetrahydrofolate dehydrogenase (MTHFD1) has been reported as a risk factor for neural tube defects (NTDs). In the present study, we aimed to investigate whether the single-nucleotide polymorphisms (SNPs) of MTHFD1 gene are associated with NTDs in a Chinese population and to determine their mechanism of action. MATERIAL AND METHODS: MTHFD1 gene was scanned in a total of 270...

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Identifiers

PMID: 26343515
DOI: 10.12659/MSM.895155
PMCID: PMC4566945

Genes

MTHFD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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