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Article

Is 5-methyltetrahydrofolate an alternative to folic acid for the prevention of neural tube defects?

Journal of perinatal medicine - 1 Sept 2013

Obeid Rima, Holzgreve Wolfgang, Pietrzik Klaus

Abstract excerpt

Women have higher requirements for folate during pregnancy. An optimal folate status must be achieved before conception and in the first trimester when the neural tube closes. Low maternal folate status is causally related to neural tube defects (NTDs). Many NTDs can be prevented by increasing maternal folate intake in the preconceptional period. Dietary folate is protective, but recommending increasing folate...

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Identifiers

PMID: 23482308
DOI: 10.1515/jpm-2012-0256

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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