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Article

Association of main folate metabolic pathway gene polymorphisms with neural tube defects in Han population of Northern China.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery - 1 Apr 2018

Fang Yulian, Zhang Ruiping, Zhi Xiufang, Zhao Linsheng, Cao Lirong, Wang Yizheng, Cai Chunquan

Abstract excerpt

PURPOSE: Neural tube defects (NTDs) are one of the most prevalent and the most severe congenital malformations worldwide. Studies have confirmed that folic acid supplementation could effectively reduce NTDs risk, but the genetic mechanism remains unclear. In this study, we explored association of single nucleotide polymorphisms (SNP) within folate metabolic pathway genes with NTDs in Han population of Northern...

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Source

Identifiers

PMID: 29392422
DOI: 10.1007/s00381-018-3730-0

Genes

MTHFD1
MTHFR
MTRR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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