Article
Preconception folic acid supplementation use and the occurrence of neural tube defects in Japan: A nationwide birth cohort study of the Japan Environment and Children's Study.
Congenital anomalies - 1 Jul 2019
Nishigori Hidekazu, Obara Taku, Nishigori Toshie, Ishikuro Mami, Sakurai Kasumi, Hoshiai Tetsuro, Saito Masatoshi, Fujiwara Ikuma, Arima Takahiro, Nakai Kunihiko, Kuriyama Shinichi, Mano Nariyasu, Metoki Hirohito, Yaegashi Nobuo
Abstract excerpt
We evaluated the relationship between preconception folic acid supplementation and the occurrence of neural tube defects (NTDs) in offspring, using data from the Japan Environment and Children's Study (a nationwide prospective birth cohort study) database. Of 92 269 participants with single pregnancies, 74 cases (offspring or fetuses) had NTDs, including 32 cases of spina bifida, 24 cases of anencephaly, and 19...
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