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Article

Folic acid, methylation and neural tube closure in humans.

Birth defects research. Part A, Clinical and molecular teratology - 1 Apr 2009

Blom Henk J

Abstract excerpt

This review provides a brief description of folate use and folic acid metabolism in relation to neural tube defect (NTD) risk. First, a meta-analysis of reduction in NTD recurrence and occurrence risk with periconceptional folic acid supplementation is presented. Second, an overview of the complex folate metabolism is given. Third, SNPs for genes involved in folate and homocysteine metabolism that have been...

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Identifiers

PMID: 19301298
DOI: 10.1002/bdra.20581

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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