Article
Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background.
The Journal of biological chemistry - 1 Jan 2000
Muramatsu Masashi, Osawa Tsuyoshi, Miyamura Yuri, Nakagawa Suguru, Tanaka Toshiya, Kodama Tatsuhiko, Aburatani Hiroyuki, Sakai Juro, Ryeom Sandra, Minami Takashi
Abstract excerpt
Down syndrome critical region (DSCR)-1 functions as a feedback modulator for calcineurin-nuclear factor for activated T cell (NFAT) signals, which are crucial for cell proliferation and inflammation. Stable expression of DSCR-1 inhibits pathological angiogenesis and septic inflammation. DSCR-1 also plays a critical role in vascular wall remodeling associated with aneurysm development that occurs primarily in...
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