Article
The miR-378c-Samd1 circuit promotes phenotypic modulation of vascular smooth muscle cells and foam cells formation in atherosclerosis lesions.
Scientific reports - 18 May 2021
Tian Shengya, Cao Yang, Wang Jinliang, Bi Yongjun, Zhong Jingquan, Meng Xiangbin, Sun Wenyu, Yang Ruixue, Gan Luping, Wang Xuping, Li Hongshi, Wang Rong
Abstract excerpt
MicroRNAs have emerged as key regulators in vascular diseases and are involved in the formation of atherosclerotic lesions. However, the atherosclerotic-specific MicroRNAs and their functional roles in atherosclerosis are unclear. Here, we report that miR-378c protects against atherosclerosis by directly targeting Sterile Alpha Motif Domain Containing 1 (Samd1), a predicted transcriptional repressor. miR-378c was...
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