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Article

Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats.

Atherosclerosis - 1 Apr 2018

Zhao Yongliang, Yang Yiqing, Xing Roumei, Cui Xueqin, Xiao Yufang, Xie Ling, You Panpan, Wang Tongtong, Zeng Li, Peng Wenhui, Li Dali, Chen Huaqing, Liu Mingyao

Abstract excerpt

BACKGROUND AND AIMS: Low-density lipoprotein receptor (Ldlr) and apolipoprotein E (Apoe) knockout (KO) mice have been widely used as animal models of atherosclerosis. However, data suggested that it is difficult to develop typical atherosclerosis in rats. To this end, Ldlr and Apoe KO rats were generated and the potential to develop novel atherosclerosis models was evaluated. METHODS: We established Apoe/Ldlr...

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Aorta, Abdominal
Aortic Diseases
Diet, High-Fat
Fatty Liver
Hyperlipidemias

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Plaque, Atherosclerotic

Rats, Transgenic

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PMID: 29459263
DOI: 10.1016/j.atherosclerosis.2018.02.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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