Article

Alternate models of acute dyslipidemia reveal divergent pathways upon atherosclerosis initiation

2020-09-03

Abstract excerpt

Atherosclerosis is thought to be initiated by the sub-intimal retention of apolipoprotein-B containing lipoproteins within susceptible sites of the vasculature. Understanding this initiation is not possible with current legacy mouse models of atherosclerosis. We created two mouse strains of inducible hypercholesterolemia based on conditional loss of apolipoprotein E or through inducible expression of a gain-of-fun...

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Literature Corpus work: 67f89108-fcbb-5150-a41f-d28591ae53d6
DOI: 10.1101/2020.09.02.279596

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