Article

Xcr1 <sup>+</sup> type 1 conventional dendritic cells are essential mediators for atherosclerosis progression

2025-05-28

Abstract excerpt

<h4>Background</h4> Atherosclerosis is characterized by lipid accumulation within plaques, leading to foam cell formation and an inflammatory response within the aortic lesions. Lipid disorders have been extensively investigated, however the cellular and molecular mechanisms that trigger the inflammatory response in atherosclerotic plaques remain far from being fully understood. Xcr1 + cDC1 cells are newly ident...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9e538002-905d-5788-9f5f-cabe766e1279
DOI: 10.1101/2025.05.23.655779

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Xcr1 <sup>+</sup> type 1 conventional dendritic cells are essential mediators for atherosclerosis progressionDOI 10.1101/2025.05.23.655779Read

A major role for RCAN1 in atherosclerosis progression.Semantic proximity Read

Clonal hematopoiesis-related mutant ASXL1 promotes atherosclerosis in mice via dysregulated innate immunity.Semantic proximity Read

Loss of Down syndrome critical region-1 leads to cholesterol metabolic dysfunction that exaggerates hypercholesterolemia in ApoE-null background.Semantic proximity Read

Integrated scRNA-seq analysis identifies conserved transcriptomic features of mononuclear phagocytes in mouse and human atherosclerosisSemantic proximity Read

Integrative single-cell and bulk RNA-seq analyses identify CD4+ T-cell subpopulation infiltration and biomarkers of regulatory T cells involved in mediating the progression of atherosclerotic plaqueSemantic proximity Read

C-C chemokine receptor 4 deficiency exacerbates early atherosclerosis in miceSemantic proximity Read

T Cells in Atherosclerosis: Key Players in the Pathogenesis of Vascular DiseaseSemantic proximity Read

Mucosal-Associated Invariant T Cells Promote Atherosclerosis Through Monocyte-Driven InflammationSemantic proximity Read

CH-related Mutant ASXL1 Promotes Atherosclerosis in Mice via Dysregulated Innate ImmunitySemantic proximity Read

HCC-1 accelerates atherosclerosis by inducing endothelial cells and macrophages pyroptosis and serves as an early diagnostic biomarkerSemantic proximity Read

PD-1 blockade-driven anti-tumor CD8 <sup>+</sup> T cell immunity requires XCR1 <sup>+</sup> dendritic cellsSemantic proximity Read

Cell-specific and divergent roles of the CD40L-CD40 axis in atherosclerotic vascular diseaseSemantic proximity Read