SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice.

doi:10.1371/journal.pone.0258408

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Article

SUR1-E1506K mutation impairs glucose tolerance and promotes vulnerable atherosclerotic plaque phenotype in hypercholesterolemic mice.

PloS one - 1 Jan 2021

Gurzeler Erika, Ruotsalainen Anna-Kaisa, Laine Anssi, Valkama Teemu, Kettunen Sanna, Laakso Markku, Ylä-Herttuala Seppo

Abstract excerpt

BACKGROUND AND AIMS: Diabetes is a major risk factor of atherosclerosis and its complications. The loss-of-function mutation E1506K in the sulfonylurea receptor 1 (SUR1-E1506K) induces hyperinsulinemia in infancy, leading to impaired glucose tolerance and increased risk of type 2 diabetes. In this study, we investigate the effect of SUR1-E1506K mutation on atherogenesis in hypercholesterolemic LDLR-/- mice....

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PMID: 34767557
DOI: 10.1371/journal.pone.0258408
PMCID: PMC8589160

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