Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CarcSeq Measurement of Rat Mammary Cancer Driver Mutations and Relation to Spontaneous Mammary Neoplasia.

Toxicological sciences : an official journal of the Society of Toxicology - 16 Jul 2021

McKim Karen L, Myers Meagan B, Harris Kelly L, Gong Binsheng, Xu Joshua, Parsons Barbara L

Abstract excerpt

The ability to deduce carcinogenic potential from subchronic, repeat dose rodent studies would constitute a major advance in chemical safety assessment and drug development. This study investigated an error-corrected NGS method (CarcSeq) for quantifying cancer driver mutations (CDMs) and deriving a metric of clonal expansion predictive of future neoplastic potential. CarcSeq was designed to interrogate subsets of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Rats, Sprague-Dawley

Share to Rats, Wistar

Source

Identifiers

PMID: 33822199
DOI: 10.1093/toxsci/kfab040

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CarcSeq Measurement of Rat Mammary Cancer Driver Mutations and Relation to Spontaneous Mammary Neoplasia.PMID 33822199Read ↗

Quantification of cancer driver mutations in human breast and lung DNA using targeted, error-corrected CarcSeq.Semantic proximity Read ↗

Tissue and Sex-Specific Performance of a Cancer Driver Based Biomarker in rasH2-Tg Mice.Semantic proximity Read ↗

Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia.Semantic proximity Read ↗

Direct Quantification of <i>in vivo</i> Mutagenesis and Carcinogenesis Using Duplex SequencingSemantic proximity Read ↗

Direct quantification of in vivo mutagenesis and carcinogenesis using duplex sequencing.Semantic proximity Read ↗

CarcSeq detection of lorcaserin-induced clonal expansion of Pik3ca H1047R mutants in rat mammary tissue.Semantic proximity Read ↗

Adopting duplex sequencing technology for genetic toxicity testing: A proof-of-concept mutagenesis experiment with N-ethyl-N-nitrosourea (ENU)-exposed rats.Semantic proximity Read ↗

Adopting Duplex Sequencing™ Technology for Genetic Toxicity Testing: A Proof-of-Concept Mutagenesis Experiment with N-Ethyl-N-Nitrosourea (ENU)-Exposed RatsSemantic proximity Read ↗

Clonal expansion of cancer driver gene mutants investigated using advanced sequencing technologies.Semantic proximity Read ↗

Error-corrected next generation sequencing - Promises and challenges for genotoxicity and cancer risk assessment.Semantic proximity Read ↗

Mutational profiles of spontaneous and radiation-related mammary carcinomas in a rat model of Brca1 haploinsufficiency.Semantic proximity Read ↗

Mutation analysis with random DNA identifiers (MARDI) catalogs Pig-a mutations in heterogeneous pools of CD48-deficient T cells derived from DMBA-treated rats.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.