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Clonal expansion of cancer driver gene mutants investigated using advanced sequencing technologies.

Mutation research. Reviews in mutation research - 1 Jan 2024

Parsons Barbara L

Abstract excerpt

Advanced sequencing technologies (ASTs) have revolutionized the quantitation of cancer driver mutations (CDMs) as rare events, which has utility in clinical oncology, cancer research, and cancer risk assessment. This review focuses on studies that have used ASTs to characterize clonal expansion (CE) of cells carrying CDMs and to explicate the selective pressures that shape CE. Importantly, high-sensitivity ASTs...

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PMID: 39369952
DOI: 10.1016/j.mrrev.2024.108514

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