Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

CarcSeq detection of lorcaserin-induced clonal expansion of Pik3ca H1047R mutants in rat mammary tissue.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Sept 2024

Faske Jennifer B, Myers Meagan B, Bryant Matthew, He Xiaobo, McLellen Florence, Bourcier Todd, Parsons Barbara L

Abstract excerpt

Lorcaserin is a 5-hydroxytryptamine 2C (serotonin) receptor agonist and a nongenotoxic rat carcinogen, which induced mammary tumors in male and female rats in a 2-yr bioassay. Female Sprague Dawley rats were treated by gavage daily with 0, 30, or 100 mg/kg lorcaserin, replicating bioassay dosing but for shorter duration, 12 or 24 wk. To characterize exposure and eliminate possible confounding by a potentially...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzazepines
Share to Carcinogens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Class I Phosphatidylinositol 3-Kinases

Share to Dose-Response Relationship, Drug

Share to Mammary Glands, Animal

Share to Mammary Neoplasms, Experimental

Share to Rats, Sprague-Dawley

Source

Open in PubMed Open full text

Identifiers

PMID: 38851877
DOI: 10.1093/toxsci/kfae070
PMCID: PMC11347771

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

CarcSeq detection of lorcaserin-induced clonal expansion of Pik3ca H1047R mutants in rat mammary tissue.PMID 38851877Read ↗

CarcSeq Measurement of Rat Mammary Cancer Driver Mutations and Relation to Spontaneous Mammary Neoplasia.Semantic proximity Read ↗

Tissue and Sex-Specific Performance of a Cancer Driver Based Biomarker in rasH2-Tg Mice.Semantic proximity Read ↗

Sequencing Chemically Induced Mutations in the Mutamouse Lacz Reporter Gene Identifies Human Cancer Mutational SignaturesSemantic proximity Read ↗

Genome-scale multi-organ analysis of mutagenic effects of ethanol and acetaldehyde in Sprague Dawley ratsSemantic proximity Read ↗

A high-throughput next-generation sequencing-based method for detecting the mutational fingerprint of carcinogens.Semantic proximity Read ↗

Mutation analysis with random DNA identifiers (MARDI) catalogs Pig-a mutations in heterogeneous pools of CD48-deficient T cells derived from DMBA-treated rats.Semantic proximity Read ↗

Assessment of in vivo chemical mutagenesis by long-read sequencing.Semantic proximity Read ↗

Chemically induced mutations in a MutaMouse reporter gene inform mechanisms underlying human cancer mutational signatures.Semantic proximity Read ↗

Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia.Semantic proximity Read ↗

Mutation discovery by targeted genomic enrichment of multiplexed barcoded samples.Semantic proximity Read ↗

Experimental analysis of exome-scale mutational signature of glycidamide, the reactive metabolite of acrylamideSemantic proximity Read ↗

Quantification of cancer driver mutations in human breast and lung DNA using targeted, error-corrected CarcSeq.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.