Article
Quantification of cancer driver mutations in human breast and lung DNA using targeted, error-corrected CarcSeq.
Environmental and molecular mutagenesis - 1 Nov 2020
Harris Kelly L, Walia Vijay, Gong Binsheng, McKim Karen L, Myers Meagan B, Xu Joshua, Parsons Barbara L
Abstract excerpt
There is a need for scientifically-sound, practical approaches to improve carcinogenicity testing. Advances in DNA sequencing technology and knowledge of events underlying cancer development have created an opportunity for progress in this area. The long-term goal of this work is to develop variation in cancer driver mutation (CDM) levels as a metric of clonal expansion of cells carrying CDMs because these...
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