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Mutational profiles of spontaneous and radiation-related mammary carcinomas in a rat model of Brca1 haploinsufficiency.

Scientific reports - 24 Feb 2026

Nakamura Yuzuki, Daino Kazuhiro, Ishikawa Atsuko, Kakinuma Shizuko, Nishimura-Yano Yukiko, Nagata Kento, Takabatake Masaru, Nishimura Mayumi, Mashimo Tomoji, Inoue Kazumasa, Imaoka Tatsuhiko

Abstract excerpt

Female carriers of a heterozygous germline mutation in BRCA1/2 have a high risk of breast cancer. Although recent research has suggested that genomic instability via BRCA1/2 haploinsufficiency contributes to the early phase of BRCA-associated carcinogenesis, insights into the role of BRCA haploinsufficiency in carcinogenesis are lacking. We previously reported that the Brca1L63X/+ rat, a model of Brca1...

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Share to BRCA1 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41735493
DOI: 10.1038/s41598-026-41240-9
PMCID: PMC13031488

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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