Article

Influence of autozygosity on common disease risk across the phenotypic spectrum

2023-02-02

Abstract excerpt

Autozygosity is associated with rare Mendelian disorders and clinically-relevant quantitative traits. We investigated associations between F ROH (fraction of the genome in runs of homozygosity) and common diseases in Genes & Health (N=23,978 British South Asians), UK Biobank (N=397,184), and 23andMe, Inc. We show that restricting analysis to offspring of first cousins is an effective way of removing confounding du...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4f1301fd-27e1-5120-83ba-959c9f01968e
DOI: 10.1101/2023.02.01.23285346

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Influence of autozygosity on common disease risk across the phenotypic spectrumDOI 10.1101/2023.02.01.23285346Read

Influence of autozygosity on common disease risk across the phenotypic spectrum.Semantic proximity Read

The impact of consanguinity on human health and disease with an emphasis on rare diseasesSemantic proximity Read

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individuals.Semantic proximity Read

Relationship between Deleterious Variation, Genomic Autozygosity, and Disease Risk: Insights from The 1000 Genomes Project.Semantic proximity Read

Estimation of non-additive genetic variance in human complex traits from a large sample of unrelated individualsSemantic proximity Read

Weighted likelihood inference of genomic autozygosity patterns in dense genotype dataSemantic proximity Read

Autozygosity-driven genetic diagnosis in consanguineous families from Italy and the Greater Middle East.Semantic proximity Read

Within-family heritability estimates for behavioural and disease phenotypes from 500,000 sibling pairs of diverse ancestriesSemantic proximity Read

Rare Genetic Variation Underlying Human Diseases and Traits: Results from 200,000 Individuals in the UK BiobankSemantic proximity Read

Genetic impact of non-consanguineous marriages in Saudi ArabiaSemantic proximity Read

Widespread recessive effects on common diseases in a cohort of 44,000 British Pakistanis and Bangladeshis with high autozygositySemantic proximity Read

Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity.Semantic proximity Read