Article
Influence of autozygosity on common disease risk across the phenotypic spectrum.
Cell - 12 Oct 2023
Malawsky Daniel S, van Walree Eva, Jacobs Benjamin M, Heng Teng Hiang, Huang Qin Qin, Sabir Ataf H, Rahman Saadia, Sharif Saghira Malik, Khan Ahsan, Mirkov Maša Umićević, Kuwahara Hiroyuki, Gao Xin, Alkuraya Fowzan S, Posthuma Danielle, Newman William G, Griffiths Christopher J, Mathur Rohini, van Heel David A, Finer Sarah, O'Connell Jared, Martin Hilary C
Abstract excerpt
Autozygosity is associated with rare Mendelian disorders and clinically relevant quantitative traits. We investigated associations between the fraction of the genome in runs of homozygosity (FROH) and common diseases in Genes & Health (n = 23,978 British South Asians), UK Biobank (n = 397,184), and 23andMe. We show that restricting analysis to offspring of first cousins is an effective way of reducing confounding...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.